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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract: Recent clinical trials involving the use of a self-complementary adeno-associated virus serotype 8-humancodon-optimized factor IX (AAV8-hFIXco) vector demonstrated encouraging efficacy with hFIX expressionto obtain a higher expression level of hFIX that potentiates the coagulant capacity of recipients, human

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 283-285 doi: 10.1007/s11684-008-0053-7

Abstract: The aim of this paper is to report a new coding variance of the gene, a candidate for autoimmune diseases. We found the variation in two families with type 2 diabetes mellitus by D-HPLC mutation screening method and confirmed our results by direct sequencing and PCR-RFLP. Although without changing the amino acid coding, the variance may have an effect on codon usage and play a role in disease development, such as type 2 diabetes mellitus. However, we cannot define the role of this variance because the frequency of the minor allele is low in the Chinese population and no homozygote of the variance was found. More research in multiple populations will be necessary to define the role of this variance.

Keywords： D-HPLC mutation     development     autoimmune     PCR-RFLP     candidate    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 584-595 doi: 10.1007/s11684-021-0844-7

Abstract: In this study, a recombinant FVIII cDNA encoding a human/rat hybrid FVIII with an enhanced procoagulantPlasmids containing human FVIII heavy chain (hHC), human light chain (hLC), and rat light chain (rLC)

Keywords： hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

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Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 303-308 doi: 10.1007/s11684-009-0060-3

Abstract: on the invasion and the related protein expression of Hela cells and the role of hypoxia inducible factorIt was concluded that the effects of hypoxia on the invasion of human cervical cancer Hela cells and

Keywords： hypoxia     actin     β     -catenin     E-cadherin     invasion    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: studied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell lines (humanhepatoma cell line HepG2, human colon cancer cell line LoVo, and human gastric cancer cell line AGS)and nontumor cell lines (human embryonic liver cell line L02 (L02 cells) and human embryonic kidney

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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System dynamics analytical modeling approach for construction project management research: A critical review and future directions

Xiaoxiao XU, Patrick X. W. ZOU

Frontiers of Engineering Management 2021, Volume 8, Issue 1,   Pages 17-31 doi: 10.1007/s42524-019-0091-7

Abstract: future research directions, namely, integration of SD with other methods, uncertainty analysis, and humanfactor analysis.

Keywords： system dynamics     construction management     problem and recommendation     research directions     literature review     humanfactor    

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Common biases in client involved decision-making in the AEC industry

Sujesh F. SUJAN, Arto KIVINIEMI, Steve W. JONES, Jacqueline M. WHEATHCROFT, Eilif HJELSETH

Frontiers of Engineering Management 2019, Volume 6, Issue 2,   Pages 221-238 doi: 10.1007/s42524-019-0026-3

Abstract: Understanding of the constitution of client involved decisions is important for future improvements of the processes. Significant decisions in construction projects are reliant on heuristic processes where assumptions are developed from past experience. The paper presents a methodology to collect empirical data in an unstructured manner utilizing participant intuition and experience regarding project level collaboration, a term easily understood by practitioners. Empirical data collected from 6 focus group discussions in Norway and 18 individual interviews in Finland is associated with biases in decision making aimed at bridging the gap of understanding and literature’s insufficient coverage. An analytic framework was developed to suit the diverse emergence of concepts to allow application of psychological principles in a structured manner to empirical data. The paper contributes by identifying types of cognitive and motivational biases in client involved decisions. The biases are found to be alleviated by one another depending on the particular application of the decision. Findings suggest that normative beliefs exist developed from past experience and habitual thinking. A number of emerged biases in this domain are alleviated from normative beliefs which are discussed in this paper.

Keywords： construction industry     social science     decision-making     client     cognitive bias     motivational bias     holistic analysis     humanfactor    

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Challenges of human–machine collaboration in risky decision-making

Frontiers of Engineering Management 2022, Volume 9, Issue 1,   Pages 89-103 doi: 10.1007/s42524-021-0182-0

Abstract: The purpose of this paper is to delineate the research challenges of human–machine collaboration in riskyTechnological advances in machine intelligence have enabled a growing number of applications in human–machineWe first summarize features of risky decision-making and possible biases of human decision-makers thereinAfterward, we review the literature on human–machine collaboration in a general decision context, fromthe perspectives of human–machine organization, relationship, and collaboration.

Keywords： human–machine collaboration     risky decision-making     human–machine team and interaction     task allocation     human–machine relationship    

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Zooming in and out of ferroptosis in human disease

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 173-206 doi: 10.1007/s11684-023-0992-z

Abstract: review, we summarize the progress in the research into ferroptosis and its regulatory mechanisms in humanWe also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease

Keywords： ferroptosis     human disease     iron metabolism     lipid peroxidation     antioxidation    

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Tackling global electricity shortage through human power: Technical opportunities from direct or indirectutilizations of the pervasive and green human energy

Dan DAI, Jing LIU

Frontiers in Energy 2012, Volume 6, Issue 3,   Pages 210-226 doi: 10.1007/s11708-012-0200-3

Abstract: With the energy and environmental problems becoming increasingly serious, human power, as a pervasiveIn this paper, the most basic features of human power are presented.The currently available human power harvesting theories and devices are briefly reviewed and compared, which are termed as human-powered grid (HPG), human-powered charger (HPC) and human-powered storageconverts human power into electricity.

Keywords： human energy harvesting     human-powered transportation     human-powered home appliances     human-powered grid(HPG)     human-powered charger (HPC)     human-powered storage (HPS)     biofuel    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract: Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 20-29 doi: 10.1007/s11684-014-0371-x

Abstract: As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs

Keywords： cellular therapy     transplantation     human umbilical cord     mesenchymal stem cells     ischemic stroke    

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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract:

Superinfection is frequently detected among individuals infected by human immunodeficiency virus type

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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An experimental analysis of human straight walking

Tao LI, Marco CECCARELLI

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 1,   Pages 95-103 doi: 10.1007/s11465-013-0357-4

Abstract:

In this paper, an experimental analysis of human straight walking has been presented.Experiments on human walking were carried out by using Cassino tracking system which is a passive cable-basedBy using experimental results, trajectories of a human limb extremity and its posture have been analyzedFurthermore, by using experimental tests, modeling and characterization of the human straight walking

Keywords： human locomotion     walking gait     characterization     humanoid robot     biped robot    

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Title Author Date Type Operation

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Journal Article

correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human

Journal Article

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

System dynamics analytical modeling approach for construction project management research: A critical review and future directions

Xiaoxiao XU, Patrick X. W. ZOU

Journal Article

Common biases in client involved decision-making in the AEC industry

Sujesh F. SUJAN, Arto KIVINIEMI, Steve W. JONES, Jacqueline M. WHEATHCROFT, Eilif HJELSETH

Journal Article

Challenges of human–machine collaboration in risky decision-making

Journal Article

Zooming in and out of ferroptosis in human disease

Journal Article

Tackling global electricity shortage through human power: Technical opportunities from direct or indirectutilizations of the pervasive and green human energy

Dan DAI, Jing LIU

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Journal Article

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

An experimental analysis of human straight walking

Tao LI, Marco CECCARELLI

Journal Article